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Proteinase-activated receptor 1 (PAR1) also known as the coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the ''F2R'' gene. PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2149 )〕 PAR-1 has multifaceted effects and plays a key role in mediating the interplay between coagulation and inflammation, which is important in the pathogenesis of inflammatory and fibrotic lung diseases.〔 ==Ligands== Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease. * SCH-530,348 SCH530348 has been recently shown to attenuate the neutrophilic inflammatory response to ''S. pneumoniae'' by reducing levels of pro-inflamamtory cytokines sucha s IL-1β and chemokines CXCL1, CCL2 and CCL7. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Coagulation factor II receptor」の詳細全文を読む スポンサード リンク
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